How could we reverse aging? | Ronald DePinho | TEDxFordhamUniversity
AI Summary
In this engaging presentation, the speaker discusses aging as a universal experience and a major health issue that leads to diseases such as cancer, diabetes, and Alzheimer’s. Highlighting a significant increase in disease incidence post-60 years of age, the speaker emphasizes understanding the molecular mechanisms of aging to identify therapeutic interventions. Key hallmarks of aging include DNA damage, chronic inflammation, and mitochondrial dysfunction, among others. The discovery of compounds, termed TAC (TUR activator compound), shows promise in reversing aging effects, notably in enhancing brain function and reducing senescent cells in experimental mouse models. The results indicate potential for extending health spans and effectively combatting age-related diseases. The talk culminates in an optimistic outlook on the future of aging science and regenerative medicine, suggesting that aging can be managed more proactively rather than reactively.